Mast cells and oral inflammation.
نویسنده
چکیده
Mast cells are mobile granule-containing secretory cells that are distributed preferentially about the microvascular endothelium in oral mucosa and dental pulp. The enzyme profile of mast cells in oral tissues resembles that of skin, with most mast cells expressing the serine proteases tryptase and chymase. Mast cells in oral tissues contain the pro-inflammatory cytokine tumour necrosis factor-alpha in their granules, and release of this promotes leukocyte infiltration during evolving inflammation in several conditions, including lichen planus, gingivitis, pulpitis, and periapical inflammation, through induction of endothelial-leukocyte adhesion molecules. Mast cell synthesis and release of other mediators exerts potent immunoregulatory effects on other cell types, while several T-lymphocyte-derived cytokines influence mast cell migration and mediator release. Mast cell proteases may contribute to alterations in basement membranes in inflammation in the oral cavity, such as the disruptions that allow cytotoxic lymphocytes to enter the epithelium in oral lichen planus. A close relationship exists among mast cells, neural elements, and laminin, and this explains the preferential distribution of mast cells in tissues. Mast cells are responsive to neuropeptides and, through their interaction with neural elements, form a neural immune network with Langerhans cells in mucosal tissues. This facilitates mast cell degranulation in response to a range of immunological and non-immunological stimuli. Because mast cells play a pivotal role in inflammation, therapies that target mast cell functions could have value in the treatment of chronic inflammatory disorders in the oral cavity.
منابع مشابه
Effects of oral consumption of Kombucha tea on mast cells of skin wounds of rats
Background: Positive effects of Kombucha tea (An old folkloric drink of Asian people) on wound healing process have been observed. Objective: To study its effects on the number of mast cells of wound bed. Materials and Methods: The study design was experimental. 42 male adult rats were randomly divided into control and experimental groups. Each group was divided into 3 subgroups. The time...
متن کاملInvestigating the Presence of Mast Cells in Odontogenic keratocyst and Radicular cyst
Background and purpose: Inflammatory cells including mast cells, with the production of inflammatory mediators such as heparin and histamine participate in the process of inflammation and jaw resorption. Considering the increasing growth of cysts and the role of mast cells in the process of bone resorption, the role of mast cells might be considered in pathogenesis and growth of cysts. The aim ...
متن کاملThe evaluation of the number of mast cells in oral lichen planus
oral lichen planus is diagnosed according to clinical and histopathological characteristics.some times all of the classical histopathological features can not be seen.in some articles the presence of mast cells have been noted below the epithelium of oral lichen planus patients.the following study was done to evaluate the number of mast cells in the histopathological sections of 20 oral lichen...
متن کاملMast cells and histopathologic variants of basal cell carcinoma
Background and aim: The stroma of basal cell carcinoma (BCC) is rich in mast cells. Morpheaform BCC has been reported to contain much more mast cells than the other types of BCC, but their significance remains unknown. In this study we investigated the significance of mast cells related to BCC and possible relationship between increased number of mast cells and clinical and histological p...
متن کاملA comparative study on the mast cells count in oral squamous cell carcinoma and normal oral mucosa
Introduction: Oral squamous cell carcinoma (OSCC) is one of the 10 most common malignant tumors and SCC accounts 94% of all oral malignancies. Mast cells are regarded as complex and multifunctional cells, playing a significant role in immunopathology . The aim of this study is to evaluate the number of mast cells in tissue sections of oral squamous cell carcinoma (OSCC) in comparison with norma...
متن کاملHistopathologic evaluation of mast cells in reticular and erosive oral lichen planus using toluidine blue staining
Introduction: Oral Lichen Planus (OLP) is one of the most common mucocutaneous lesion, and its etiologic factors have not been elucidated yet. OLP has two different clinical forms including reticular and erosive. Mast cells function in non-specific immunology is an etiologic factor involved in the formation of lichen planus. This study aimed at determining the pattern of mast cells presence in ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Critical reviews in oral biology and medicine : an official publication of the American Association of Oral Biologists
دوره 14 3 شماره
صفحات -
تاریخ انتشار 2003